GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration. There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone. GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C modulates the interaction of GAP-43 with actin and may also affect neurotransmitter release during forms of plasticity like LTP. GAP-43 Antibody is ideal for researchers interested in neuroscience research.
应用类型
ELISA,IF Microscopy,Western Blot,
免疫原
Anti-GAP-43 Antibody was produced in chickens by repeated immunizations with a synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAP43 conjugated to KLH.
来源宿主
Chicken
反应性
H. sapiens (Human); Mus musculus (Mouse); Rattus (Rat)
保存建议
Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilut
