XRCC1 (X-Ray Repair Cross Complementing 1) is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Diseases associated with XRCC1 include Spinocerebellar Ataxia, Autosomal Recessive 26 and Gastric Cardia Carcinoma. Anti-XRCC1 Antibody is useful for researchers interested in Cancer research and DNA repair.
应用类型
ELISA,IF Microscopy,Western Blot,
免疫原
Anti-XRCC1 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a N-Terminal portion of human XRCC1 conjugated to Keyhole Limpet Hemocyanin (KLH). A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to human and 91% to mouse, rat, and Chinese hamster.
来源宿主
Chicken
反应性
H. sapiens (Human); Mus musculus (Mouse)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
