There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF handcontaining proteins required for the traffic of channelforming Kv4 K+ subunits to the plasma membrane. KChiP2 expression has been found to be significantly decreased in hypertrophy and heart failure, and does so thru modulatin of intracellular concentration and calcineurin/NFAT pathways. It has also been found that KChiP2 also functionally modulates the Cav1.2 goverened Ltype calcium channel through a direct interaction between KChiP2 and the amino-terminus of Cav1.2.
应用类型
Immunohistochemistry,IF Microscopy,Western Blot,
免疫原
KChlP2 K+ channel Antibody was produced in mice by repeated immunizations raised against a fusion protein of full length of rat KChIP2b.
来源宿主
Mouse
反应性
H. sapiens (Human); Mus musculus (Mouse); Rattus (Rat)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
