- 中文名称
HLI 373（盐酸盐）
- 英文名字
- HLI 373 (hydrochloride)
- 供应商
- 开曼生物
- 产品货号
- 18221-1
- 产品报价
- ￥1/50mg
- 产品说明书
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- 产品新闻
- 背景资料
- Hdm-2 (human double minute-2; Mdm-2 in mouse) is a ubiquitin ligase and key negative regulator of p53, targeting it for proteasomal degradation. Overexpression of Hdm-2 in some tumors leads to inactivation of p53, thereby allowing tumor cells to escape p53-induced apoptosis.{13684} HLI 373 is an inhibitor of Hdm-2.{29613} At concentrations of 5-50 ?M, it selectively inhibits autoubiquitylation of Hdm-2 as well as the ubiquitylation and degradation of p53.{29613} Through these actions, HLI 373 stabilizes p53 and increases p53-dependent transcription, inducing apoptosis of transformed cells, tumor cells, and mouse embryo fibroblasts harboring wild-type p53.{29613}
- 产品描述
- An inhibitor of Hdm-2 that inhibits autoubiquitylation of Hdm-2 as well as the ubiquitylation and degradation of p53; stabilizes p53 and increases p53-dependent transcription, inducing apoptosis of transformed cells, tumor cells, and MEFs harboring wild-type p53
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