Selective inhibitor of TGF-B type-I receptor (TGF-B RI, TGFR-I, TBR-I, ALK-5) (IC50 values are 59, 400 and 1400nM for TGR-B RI, TGF-B RII and MLK-7K respectively). Inhibits TGF-B-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.CAS Number:396129-53-6Molecular Formula:C₁₇H₁₂N₄Molecular Weight::272.3Appearance:Very Dark Brown SolidSolubility:DMSO (Slightly, Heated)Storage:Refrigerator
