CK-1827452 is a diaryl urea compound that increases cardiac myosin ATPase activity in a dose-dependent manner that is selective for cardiac myosin over non-cardiac myosins. It promotes myosin cross-bridge formation, increasing the duration and amount of myocyte contraction without affecting intracellular calcium or cAMP. It has been shown to increase cardiac efficiency in clinical studies of patients with chronic heart failure.Synonyms:Methyl 4-[[2-Fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate; 4-[[2-Fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-1-piperazinecarboxylic Acid Methyl Ester; Omecamtiv MecarbilCAS Number:873697-71-3Molecular Formula:C₂₀H₂₄FN₅O₃Molecular Weight:401.43Appearance:White SolidPurity:≥98%Melting Point:187-190ºCSolubility:DMSO (Slightly), Methanol (Slightly)Storage:-20°C Freezer
