- 中文名称
[2R- [2α，2（S *）,,3α，6β[2S *，3E，5E，7E，9S *，11R *，13R *，14R *， 15E，17R *，19E，21R *，22（1S *，3R *，4R *））]]]]-1. [oxo [tetrahydro-‐2-hydroxy- 6- [14-羟基-22-（4-羟基-3-甲氧基环己基）-2,13-二甲氧基-3,9,11,15,17 ，21-六甲基-12、
- 英文名字
- [2R-?[2
- 供应商
- 开曼生物
- 产品货号
- 16158-500
- 产品报价
- ￥1/500ug
- 产品说明书
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- 产品新闻
- 背景资料
- Rapamycin (Item No. 13346) is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin (Item No. 13346) resulting from ester hydration followed by dehydration.{26501} It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay.{26501} Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells.{26499} Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species.{26500} While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.{26502}
- 产品描述
- A nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration; secreted from cells by P-glycoprotein; poorly activates mTOR but, like rapamycin, inhibits the proteasome
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