Gö6976 is an ATP-competitive PKC inhibitor specific for Ca2+-dependent PKCalpha (IC50= 2.3nM) and PKCBeta1 (IC50 = 6.2nM) isozymes (1). It is also a potent inhibitor of PKD (IC50= 20nM) (2). Researchers have demonstrated that Gö6976 blocks JNK activation (3-5) and inhibits PKCalpha-mediated, TPA-stimulated phosphorylation of CREB at Ser133 (6,7). Gö6976 is also an effective inhibitor of the tyrosine kinases Jak2 and FLT3 (8), as well as TrkA and TrkB (9).Solubility:~25mg/ml (DMSO).Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
产品形式
该产品为冻干粉形式，缓冲液为：DSMO。
保存建议
接收到Gö6976 (ATP-competitive PKC Inhibitor Specific for Ca2+-dependent PKCalpha and PKCBeta1)产品后，置于-20°C温度下保存。
