- 中文名称
MLL1/WARD complex -human recombinant) (250 ug)
- 英文名字
- KMT2A|Mixed-Lineage Leukemia-1|MLL Core Complex, MLL1/WARD complex -human recombinant)
- 供应商
- Cayman
- 产品货号
- 10945-250
- 产品报价
- ￥19600/250 ug
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- The MLL complex methylates histone 3 at lysine 4 -H3K4) to upregulate transcription. MLL1 is the catalytic subunit and contains the core components WDR5, Ash2L, and RbBP5 -MLL/WAR complex). MLL1 alone exhibits a low basal methyltransferase activity, but is enhanced 300-fold by the addition of the WAR components. A further 2-fold activation has been reported with the addition of DPY-30 -MLL/WARD complex). The MLL core complex colocalizes with RNA Polymerase II on chromosomes and is involved in the transition of paused Pol II to actively-transcribing Pol II. Misregulation of MLL1 by fusion of its non-catalytic N-terminus to any of >50 other proteins leads to leukemia, possibly due to release of paused Pol II at developmentally important sites such as the Hox family of genes. Wild-type MLL1 is targeted to Hox genes through interactions with menin, and is thus important for proper development.,The Cayman MLL1/WARD complex with DPY-30 is supplied as five tubes. Combining the five tubes will result in an equimolar ratio of MLL1, WDR5, Ash2L, and RbBP5. DPY-30, which binds Ash2L as a heterodimer, will be in a two molar excess of the MLL1/WAR components.
- 产品描述
- Source: Active recombinant proteins expressed in E. coli
- 产品形式
- 保存建议
- -80
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
