Interleukin-1 Receptor Type 2 (IL-1RII) ins a non-signaling receptor for IL1A, IL1B and IL1RN and reduces IL1B activities. It serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. It also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
应用类型
ELISA,Immunoprecipitation,Western Blot,
免疫原
This whole rabbit serum was prepared by repeated immunizations with recombinant human IL-1R type II.
来源宿主
Rabbit
反应性
H. sapiens (Human); Primate
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
