- 中文名称
CAY10651 (1 mg)
- 英文名字
- CAY10651, 3-fluoro-5-(2-methylbenzo(d)thiazol-5-yl)-benzonitrile
- 供应商
- Cayman
- 产品货号
- 10820-1
- 产品报价
- ￥420/1 mg
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Glutamate, the major excitatory neurotransmitter in the CNS, signals through both ionotropic and metabotropic glutamate receptors. Of the eight metabotropic glutamate receptors -mGlus) discovered thus far, development of inhibitors to mGlu5 has been given significant attention in preclinical models of disease, including pain, anxiety, gastresophageal reflux disease, Parkinson s associated dyskinesia, and fragile X syndrome, as well as in animal models of drug addiction. CAY10651 is a noncompetitive antagonist -negative allosteric modulator) of mGlu5 that demonstrates an IC50 value of 61 nM in a calcium mobilization assay and a Ki value of 477 nM in a radioligand binding assay. A 10 uM concentration of CAY10651 results in a near complete blockade of the glutamate response in cortical astrocytes. A 30 mg/kg dose of CAY10651 in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.
- 产品描述
- A noncompetitive antagonist of mGlu5 -IC50 = 61 nM; Ki = 477 nM); 10 uM results in a near complete blockade of the glutamate response in cortical astrocytes; 30 mg/kg in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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