- 中文名称
Anti-Mouse Pentraxin-3
- 英文名字
- Anti-Mouse Pentraxin-3
- 供应商
- ReliaTech
- 产品货号
- 103-M452
- 产品报价
- ￥询价/100ug
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- Pentraxin 3, also known as TSG14, was initially identified as a TNFα or IL1β inducible gene. It belongs to the pentraxin family, which was named originally for the homo pentameric structure formed by its members. The pentraxin family is divided into two subfamilies: the “short” and the “long” pentraxins with approximate molecular weights of 25 kDa and 50 kDa, respectively. TSG14 is a member of the long pentraxin subfamily, which also includes the Xenopus laevis XLPXN1, the guinea pig apexin/p50, the rat neuronal pentraxin I (NPI) and NPR, the human neuronal pentraxin II (NPTX2) and the human neuronal activityrelated pentraxin. Mature secreted PTX3 contains a pentaxinlike domain at its carboxyterminus that shares 23-28% amino acid (aa) sequence similarity to Creactive protein (CRP) and serum amyloid P component (SAP), which belong to the short pentraxin subfamily. However, the Nterminal sequence of TSG 14 does not share aa sequence homology with any of the “short” pentaxins. Unlike CRP and SAP, which forms pentamers only, TSG14 forms both pentameric and higher ordered oligomers. Similar to CRP and SAP, TSG14 binds to the complement cascade component C1q. However, TSG14 does not bind to phosphoethanolamine, phosphocholine, or high pyruvate agarose, which are known ligands for CRP and SAP. While CRP and SAP are primarily produced in the liver, TSG14 expression is strongly upregulated by TNFα, IL1β, and bacterial LPS in peripheral fibroblasts, endothelial cells, and macrophages. At the amino acid level, human and mouse TSG14 share 88% aa sequence homology. TSG14 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that TSG14 may be a potential mediator of immune response. TSG14 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that TSG14 transgenic mice are more resistant to sepsis and endotoxemia compared to wildtype during inflammatory injury. Increased expression of TSG14 may enhance the immune response to protect the host from infection.
- 应用类型
- WB
- 免疫原
- 该Anti-Mouse Pentraxin-3的详细信息查看ReliaTech提供的产品说明书。
- 来源宿主
- 该Anti-Mouse Pentraxin-3的详细信息查看ReliaTech提供的产品说明书。
- 反应性
- 该Anti-Mouse Pentraxin-3的详细信息查看ReliaTech提供的产品说明书。
- 保存建议
- 该Anti-Mouse Pentraxin-3的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- 其他
- ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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