- 中文名称
Anti-Mouse MBL-2
- 英文名字
- Anti-Mouse MBL-2
- 供应商
- ReliaTech
- 产品货号
- 103-M434
- 产品报价
- ￥询价/100ug
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- Mannan binding lectin (MBL) belongs to the collectin family of innate immune defense proteins, which binds to an array of carbohydrate patterns on pathogen surfaces. Collectin family members share common structural features: a cysteine rich aminoterminal domain, a collagen like region, an α helical-coiled-coil neck domain and a carboxy terminal Ctype (Ca ++dependent) lectin or carbohydrate recognition domain (CRD). MBL homotrimerizes to form a structural unit joined by Nterminal disulfide bridges. These homotrimers further associates into oligomeric structures of up to 6 units. Whereas two forms of MBL proteins (MBL1, also known as SMBP or MBLA and MBL2, also known as LMBP or MBLC) exist in rodents and other animals, only one functional MBL protein is present in humans. Mouse MBL2 shares approximately 52% and 60% aa sequence identity with mouse MBL1 and human MBL, respectively. In mouse, MBL1 and MBL2 are the only collectins that can activate complement via the lectin complement pathway. Serum oligomeric MBL associates with MBL-associated serine protease (MASP) proenzymes. The MBLMASP proenzyme complex preferentially interact with sugar patterns containing mannose, glucose, L-fucose, or N-acetylglucosamine present at a terminal nonreducing postion on the cell surface of various pathogens and certain tumor cells. This interaction induces proenzyme activation and the triggering of the complement cascade, resulting in opsonization and pathogen removal via humoral and cellular immune responses. MBL does not recognize selfcomponents or glycoproteins from other higher animals due to the presence of terminal sialic acid or galactose that interrupts the repeating carbohydrate structures. A number of membrane receptors for MBL, including C1q phagocytic receptor (C1qRp), calreticulin (also known as C1qR), and CR1 (CD35), have been described. Interactions with these receptors may also be important in stimulating phagocytosis. Mouse MBL 1 and MBL2 are produced primarily in the liver and are secreted into the blood stream. In addition, mouse MBL1 is also expressed in lung, kidney, and testis while MBL2 is expressed in kidney, thymus, and small intestine.
- 应用类型
- WB
- 免疫原
- 该Anti-Mouse MBL-2的详细信息查看ReliaTech提供的产品说明书。
- 来源宿主
- 该Anti-Mouse MBL-2的详细信息查看ReliaTech提供的产品说明书。
- 反应性
- 该Anti-Mouse MBL-2的详细信息查看ReliaTech提供的产品说明书。
- 保存建议
- 该Anti-Mouse MBL-2的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- 其他
- ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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