Lysosomes are intracytoplasmic organelles that are found within leukocytes (granulocytes, neutrophils, basophils and eosinophils) and function as storage granules for small particles. Lysosomes actively support subcellular protein degradation mechanisms through fusion with cellular organelles such as phagocytic vacuoles and the plasma membrane. Lysosome fusion to the plasma membrane, known as exocytosis, releases the contents of the vesicle into the extracellular environment. The lysosomal integral membrane proteins I–III, known as LIMP-I, LIMP-II and LIMP-III, localize from the trans-Golgi network to lysosomes via an AP-3-dependent pathway that may involve AP-1 and Clathrin. LIMP I-III are protein markers for the lysosome organelle. These markers are exceptionally useful for microscopy studies, cellular fractionation validation and studies pertaining to protein trafficking through the secretory pathway.
应用类型
WB
免疫原
该Anti-Mouse LIMP-II的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Mouse LIMP-II的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Mouse LIMP-II的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Mouse LIMP-II的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
