Anti-Mouse Frizzled-8-Anti-Mouse Frizzled-8-一抗-艾美捷科技有限公司

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背景资料: Wnt signaling is involved in a variety of developmental processes including cell fate determination, cell polarity, tissue patterning and control of cell proliferation. Members of the Frizzled family of proteins serve as receptors for the Wnt signaling pathway. The founding member of this family was identified in Drosophilia based on its role in tissue polarity in the adult cuticle and named for the disorganized appearance of bristle hairs on the mutant. Mouse Frizzled8 (mFrz8) was originally cloned in a PCR screen to identify additional Frizzled family members in vertebrates. There are nine murine Frizzled genes and 10 human Frizzled genes identified to date. The predicted structure of Frizzled proteins is similar among all family members, containing a divergent N-terminal signal peptide, a highly conserved extracellular cysteine-rich domain, a seven-pass transmembrane region, and a variablelength C-terminal tail. The most conserved regions of the Frizzled proteins are the extracellular cysteine rich domain (CRD) which spans approximately 120 amino acid residues and contains 10 invariant cysteines, and the seven transmembrane domains. Mouse Frizzled8 is 685 amino acid residues long and shows 95% and 82% amino acid identity to human and Xenopus Frizzled8, respectively. Like other family members, Frizzled8 has a complex expression pattern in the mouse embryo. It is expressed in the neural tube, brain, eye, somites, gut and bronchial arches.

保存建议: 该Anti-Mouse Frizzled-8的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

其他: ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。