- 中文名称
Anti-Mouse Dectin-2
- 英文名字
- Anti-Mouse Dectin-2
- 供应商
- ReliaTech
- 产品货号
- 103-M371
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
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- 产品新闻
- 背景资料
- Dectin2α or Dectin2, also known as CLEC6A, CLECSF10, and NKCL, belongs to the Ctype lectin family of transmembrane immune regulatory glycoproteins. Dectin 2α, CLEC4A/DCIR, CLEC4B/DCAR, CLEC4C/DLEC, CLEC4D/MCL, and CLEC4E/mincle constitute a subgroup of these molecules that exhibit approximately 40% amino acid (aa) sequence identity in their extracellular domains (ECD) and have a conserved cysteine spacing in their carbohydrate recognition domains (CRD). Mature mouse Dectin2α consists of a short cytoplasmic tail, a transmembrane segment, and an ECD with a stalk region and one CRD. Alternate splicing leads to partial deletion of the transmembrane segment and stalk ( β isoform) or a portion of the CRD (γ isoform). The full length Dectin2α isoform is a 27 kDa molecule that is primarily expressed on the surface of tissue macrophages and their precursors. The CRD of Dectin2α contains an EPN motif which is characteristic of calciumdependent mannosebinding lectins. Dectin2α selectively interacts with high mannose structures in the Man9GlcNAc2 configuration. It mediates the recognition of a variety of microorganisms, particularly the filamentous forms of yeast and fungii. The short cytoplasmic tail does not contain signaling motifs but mediates association with the ITAMcontaining Fc receptor γ subunit in macrophages. Ligation of Dectin2α induces tyrosine phosphorylation of the γ subunit, activation of NFκB, and enhanced release of TNFα and IL1ra. Macrophage Dectin2α is upregulated in vivo by inflammatory stimuli and UVB irradiation. It mediates the breaking of UVinduced tolerance by interacting with CD4+CD25+ regulatory T cells which then induce dendritic cells to release IL4, IL10, and TGFβ. Within the ECD, mouse Dectin2α shares 71% aa sequence identity with human and bovine Dectin2.
- 应用类型
- WB
- 免疫原
- 该Anti-Mouse Dectin-2的详细信息查看ReliaTech提供的产品说明书。
- 来源宿主
- 该Anti-Mouse Dectin-2的详细信息查看ReliaTech提供的产品说明书。
- 反应性
- 该Anti-Mouse Dectin-2的详细信息查看ReliaTech提供的产品说明书。
- 保存建议
- 该Anti-Mouse Dectin-2的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- 其他
- ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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