- 中文名称
Anti-Mouse Dectin-1
- 英文名字
- Anti-Mouse Dectin-1
- 供应商
- ReliaTech
- 产品货号
- 103-M370
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
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- 产品新闻
- 背景资料
- Dectin1, also known as CLEC7A and the β-glucan receptor, is a 43 kDa type II transmembrane C-type lectin that functions in the innate immune response to fungal pathogens. Although Dectin1 resembles other CLEC molecules structurally, it binds ligands in a calciumindependent manner. Mature mouse Dectin1 is a 244 amino acid (aa) glycoprotein that consists of a short ITAMcontaining cytoplasmic tail, a transmembrane segment, and a stalk and carbohydrate recognition domain (CRD) in the extracellular domain. The CRD of mouse Dectin1 shares 61%, 60%, and 87% aa sequence identity with that of bovine, human, and rat Dectin1, respectively. It shares 25% 34% aa sequence identity with the CRD of other subgroup members CLEC1, CLEC2, CLEC9A, CLEC12B, LOX1, and MICL. Mouse Dectin1 is alternately spliced, generating a variant that lacks the stalk region. Mouse Dectin1 is expressed on monocytes, macrophages, and neutrophils, and on some populations of dendritic cells and T cells. It is upregulated on macrophages by GM-CSF, IL4, or IL13 and downregulated by dexamethasone, IL10, or LPS. The CRD selectively binds βglucan polymers, a major component of yeast and mycobacterial cell walls. Yeast βglucan is accessible to Dectin1 only at sites of cell budding, and Dectin1 does not recognize the filamentous form of yeast. Dectin1 mediates the phagocytosis of zymosan particles and intact yeast. It colocalizes with TLR2 in the presence of zymosan, and the two receptors cooperate in ligand recognition and the propagation of proinflammatory signaling. Dectin1 interaction with the tetraspanin CD37 increases its stability on the cell membrane and inhibits ligandinduced signaling. Genetic knockout of Dectin1 in mice increases their susceptibility to pathogenic infection.
- 应用类型
- WB
- 免疫原
- 该Anti-Mouse Dectin-1的详细信息查看ReliaTech提供的产品说明书。
- 来源宿主
- 该Anti-Mouse Dectin-1的详细信息查看ReliaTech提供的产品说明书。
- 反应性
- 该Anti-Mouse Dectin-1的详细信息查看ReliaTech提供的产品说明书。
- 保存建议
- 该Anti-Mouse Dectin-1的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- 其他
- ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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