CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA-4 is up-regulated rapidly following T cell activation and CD28 ligation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28.
应用类型
WB, FC, N
免疫原
该Anti-Mouse CTLA-4的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Mouse CTLA-4的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Mouse CTLA-4的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Mouse CTLA-4的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
