Members of the UNC5H family are best known as receptors for the axon guidance molecule netrin. Structurally, UNC5Hs have two Ig and two thrombospondin type 1 domains in their extracellular region, and a conserved ZU-5 domain, a deleted in colorectal cancer (DCC)-binding domain, and a C-terminal death domain in their cytoplasmic region. In general, they mediate the chemorepulsive effects of netrin, while the other netrin receptor subtype, DCC, mediates attraction. Members of the UNC5H family have also been implicated as tumor suppressors and regulators of apoptosis.
应用类型
WB, IHC (P)
免疫原
该Anti-Human UNC5H3的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Human UNC5H3的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Human UNC5H3的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Human UNC5H3的详细信息查看ReliaTech提供的产品说明书。溶解建议:Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.