- 中文名称
Anti-Human PD-L2
- 英文名字
- Anti-Human PD-L2
- 供应商
- ReliaTech
- 产品货号
- 101-M604
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
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- 产品新闻
- 背景资料
- T cells require a signal induced by the engagement of the T cell receptor and a “costimulatory” signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. Members of the B7 superfamily of counter-receptors were identified by their ability to interact with costimulatory molecules found on the surface of T cells. Members of the B7 superfamily include B71 (CD80), B72 (CD86), B7H1 (PDL1), B7H2 (B7RP1), B7H3, and PDL2 (B7DC). B7 proteins are immunoglobulin (Ig) superfamily members with extracellular IgV-like and IgC-like domains and short cytoplasmic domains. Among the family members, they share from 20-40% amino acid (aa) sequence identity. The cloned human PDL2 cDNA encodes a 273 aa type I membrane precursor protein with a putative 20 aa signal peptide, a 201 aa extracellular region containing one V-like and one C-like Ig domain, a 24 aa transmembrane region, and a 28 aa cytoplasmic domain. The extracellular domains of mouse and human PDL2 share approximately 70% aa sequence identity. PDL2 is one of two ligands for programmed death1 (PD1), a member of the CD28 family of immunoreceptors. The other identified ligand is PDL1. Human PDL1 and PDL2 share approximately 41% aa sequence identity and have similar functions. PDL2 is broadly expressed in tissues. Highest expression was detected by Northern blot analysis in heart, placenta, liver, pancreas, spleen, and lymph node. Lower amounts of expression were observed in lung, smooth muscle, and thymus. Expression of PDL2 on antigen presenting cell has been examined in detail. Resting B cells, monocytes and dendritic cells do not express PDL2, expression however can be induced by LPS or BCR activation in B cells, INFγ treatment in monocytes, or LPS plus IFN γ treatment of dendritic cells. PD L2 expression is also up regulated in a variety of tumor cell lines. On previously activated T cells, PDL2 interaction with PD1 inhibits TCRmediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. In contrast, a costimulatory function for the PDL2 on resting T cells activated with suboptimal TCR signals has also been reported.
- 应用类型
- WB
- 免疫原
- 该Anti-Human PD-L2的详细信息查看ReliaTech提供的产品说明书。
- 来源宿主
- 该Anti-Human PD-L2的详细信息查看ReliaTech提供的产品说明书。
- 反应性
- 该Anti-Human PD-L2的详细信息查看ReliaTech提供的产品说明书。
- 保存建议
- 该Anti-Human PD-L2的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- 其他
- ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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