Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.
应用类型
WB
免疫原
该Anti-Human gp-130的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Human gp-130的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Human gp-130的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Human gp-130的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
