Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. A role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. IGSF4 is expressed broadly, including on epithelia, neurons, a subset of tonsillar B cells and a rare splenic T zone-restricted BCDA3+ dendritic cell population which interacts with CRTAM.
应用类型
WB, FC
免疫原
该Anti-Human CRTAM的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Human CRTAM的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Human CRTAM的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Human CRTAM的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
