TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
应用类型
WB, IHC (P)
免疫原
该Anti-Human TIMP-1的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Human TIMP-1的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Human TIMP-1的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Human TIMP-1的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
