中文名称

14,15-Leukotriene E4 (500 ug)

英文名字

Eoxin E4|EXE4|14,15-LTE4, 14,15-Leukotriene E4, 15S-hydroxy-14R-(S-cysteinyl)-5Z,8Z,1E,12E-eicosatetraenoic acid

供应商

Cayman

产品货号

10011362-500

产品报价

￥23968/500 ug

产品说明书

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购买方式

产品新闻

背景资料

Leukotrienes -LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase -5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency compared LTC4, but approximately 100-fold greater potency than histamine.

产品描述

A metabolite of 14,15-LTC4 and 14,15-LTD4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency compared LTC4, but approximately 100-fold greater potency than histamine

产品形式

保存建议

-80

其他

Cayman Chemical

注意

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