中文名称

Farnesyl Thiosalicylic Acid (1 mg)

英文名字

FTS|Salirasib, Farnesyl Thiosalicylic Acid, 2-[[(2E,6E)-3,7,11-trimethyl-2,6,1-dodecatrien-1-yl]thio]-benzoic acid

供应商

Cayman

产品货号

10010501-1

产品报价

￥84/1 mg

产品说明书

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产品新闻

背景资料

Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid -FTS) is an inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 uM. It does not inhibit Ras farnesylation in vitro and although FTS does inhibit prenylated protein methyltransferase -PPMTase) in cell-free systems with a Ki value of 2.6 uM, it is relatively ineffective at inhibiting methylation in whole cells. Treatment of chow-fed ApoE-deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls.

产品描述

An inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation; inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 uM

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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