- 中文名称
CAY10526 (50 mg)
- 英文名字
- CAY10526, 4-(benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one
- 供应商
- Cayman
- 产品货号
- 10010088-50
- 产品报价
- ￥21070/50 mg
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- Prostaglandin E2 -PGE2) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both cyclooxygenase-2 -COX-2) and microsomal PGE synthase-1 -mPGES-1). CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 uM without any effect on COX-2 expression.
- 产品描述
- An inhibitor of mPGES-1 expression; inhibits PGE2 production in LPS-stimulated RAW 264.7 cells -IC50 = 1.8 uM) without affecting COX-2 expression
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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