- 中文名称
D-myo-Inositol-1,3,4,5,6-pentaphosphate -ammonium salt) (5 mg)
- 英文名字
- Ins(1,3,4,5,6)P5|1,3,4,5,6-IP5 (sodium salt), D-myo-Inositol-1,3,4,5,6-pentaphosphate -ammonium salt), D-myo-inositol-1,3,4,5,6-penta(hydrogen phosphate), decaammonium salt
- 供应商
- Cayman
- 产品货号
- 10009851-5
- 产品报价
- ￥24010/5 mg
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Inositol-1,3,4,5,6-pentaphosphate -Ins-1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It can be interconverted with Ins-3,4,5,6)P4 by a 1-kinase/1-phosphatase cycle, as well as with Ins-1,4,5,6)P4 in a 3-kinase/3-phosphatase cycle. Ins-1,3,4,5,6)P5 inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells. It exhibits antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mice. Ins-1,3,4,5,6)P5 binds to the PH domain of Grp1 with a Kd of 590 nM.
- 产品描述
- A member of the inositol phosphate -InsP) family of small, soluble second messengers; inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells; exhibits antiangiogenic activity as well as antitumor effects; binds to the PH domain of Grp1 with a Kd of 590 nM.
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
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