- 中文名称
ChREBPDBD WB即用型对照 (1 ea)
- 英文名字
- ChREBP DBD Western Ready Control (1 ea)
- 供应商
- Cayman
- 产品货号
- 10009753-1
- 产品报价
- ￥714/1 ea
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- The Carbohydrate Response Element-binding Protein -ChREBP) is a member of the basic helix-loop-helix leucine zipper transcription factor family. Under conditions of low glucose, ChREBP is phosphorylated which sequesters the transcription factor in the cytoplasm. Under conditions of elevated glucose, one of its metabolites, xylulose 5-phosphate activates Protein Phosphatase 2A -PP2A) which dephosphorylates ChREBP at Ser196. Dephosphorylated -Ser196) ChREBP translocates into the nucleus where it is further dephosphorylated at Thr666 by PP2A. The second dephosphorylation allows ChREBP to bind to the carbohydrate response element -CRE) within the promoter of the L-type pyruvate kinase -L-PK) gene, as well as a subset of lipogenic enzymes. Activation of ChREBP by high glucose in the liver occurs independently of insulin concentrations. The inactivation of ChREBP has been proposed as a potential method for reducing obesity and also improving glucose tolerance.
- 序列
- 来源宿主
- 溶解建议
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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