中文名称

C-12 NBD-dihydro-Ceramide (25 mg)

英文名字

N-C12-NBD-D-erythro-dihydro-Sphingosine, C-12 NBD-dihydro-Ceramide, N-[(1,2)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-dodecanamide

供应商

Cayman

产品货号

10008097-25

产品报价

￥40670/25 mg

产品说明书

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产品新闻

背景资料

Ceramidase catalyzes the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. Three isoforms of ceramidases -acid, neutral, and alkaline) have been characterized based on differences in their catalytic pH optimum. C-12 NBD-dihydro-ceramide is a fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone. C-12 NBD ceramide, which contains the C-4/C-5 double bond, is a fluorescent ceramidase substrate that can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources. C-12 NBD-dihydro-ceramide may exhibit reduced activity in ceramidase assays compared to C-12 NBD ceramide. This is based on the observation that saturation of the C-4/C-5 sphingosine bond in C-16-ceramide results in approximately a 10-fold reduction in efficiency as a substrate for rat brain ceramidase compared to the unsaturated substrate. However, experimental characterization of C-12 NBD-dihydro-ceramide as a ceramidase substrate needs to be performed.

产品描述

A fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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