SETD1A is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional activation. SETD1A shows a non-overlapping localization with SETD1B, suggesting that both proteins play a specific role in the epigenetic control of chromatin structure and gene expression. Anti-Setd1a Antibody is ideal for research in Epigenetics and Gene Expression.
应用类型
ELISA,Western Blot,
免疫原
Anti-Setd1a Antibody was produced in rabbits by repeated immunizations with three different synthetic peptides of mouse Setd1a: two containing an amino acid sequence from the N-terminal region of the protein and one containing an amino acid sequence from the internal region of the protein.
来源宿主
Rabbit
反应性
Mus musculus (Mouse)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
