Set9 is a histone methyltransferase which specifically methylates lysine 4 of histone H3 being a specific tag for epigenetic transcriptional activation. Further, methylation of histone H3K4 by Set9 precludes deactylation of H3 by the NuRD complex and impairs Suv39h1-mediated methylation of H3K9. Set9 also methylates the tumor suppressor p53 at lysine 372, thereby enchancing its stability. IT contains a SET domain but lacks the pre- and post-SET domains. Anti-Set9 Antibody is ideal for research in Epigenetics, Gene Expression and Chromatin Remodeling.
应用类型
Western Blot,
免疫原
Anti-SET9 Antibody was produced in rabbits by repeated immunizations with a recombinant protein of human Set9.
来源宿主
Rabbit
反应性
H. sapiens (Human)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
