Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. Tool to study hedgehog (Hh) signaling pathway. SAG activity inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CStable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.