Cell permeable smoothened (Smo) agonist. Shown to induce Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations.Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CStable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.