Induces neuritogenesis. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic beta-subunit. Apoptosis inducer. Anticancer compound. Upregulates HSP70 and HSP22. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Inhibits NF-kappaB activation by inhibiting IkappaB degradation. Cathepsin A inhibitor. gamma-Secretase activity inhibitor. Anti-adipogenic.Storage and Stability:Short-term Storage: +4°CLong-term Storage: -20°CStable for at least 3 years after receipt when stored at -20°C.
