The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.Storage and Stability:Short-term Storage: -20°CLong-term Storage: -20°CStable for at least 1 year after receipt when stored at -20°C.
产品形式
艾美捷向您提供的IL-1alpha (mouse) Matched Pair Detection Set (Interleukin-1alpha)产品形式查看产品说明书，建议按照产品说明书进行应用操作。
保存建议
接收到IL-1alpha (mouse) Matched Pair Detection Set (Interleukin-1alpha)产品后，置于-20°C/-20°C温度下保存。
