DNMT1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities (1). DNMT1 enzyme is crucial for stable expression and function in vivo (2). DNMT1 is essential for maintenance of DNA methylation and the interaction of DNMT1 with the replication machinery is not strictly necessary for maintenance of DNA methylation, but improves its efficiency. DNMT1 is necessary and sufficient to maintain global methylation and aberrant CpG island methylation in human cancer cells. DNMT1 Protein is ideal for investigators involved in Signaling Proteins, Acetyl/Methyltransferase Proteins, Apoptosis/Autophagy, Cancer, Cell Cycle, and Neurobiology research.
序列
该【干冰】DNMT1 recombinant protein-GST fusion protein - 010-001-R85的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】DNMT1 recombinant protein-GST fusion protein - 010-001-R85的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】DNMT1 recombinant protein-GST fusion protein - 010-001-R85的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
