Macrophage Inflammatory Protein-3-beta (CCL 19, of the intercrine beta chemokine CC family) is an important secreted chemoattractant for dendritic cells, antigen-engaged B-cells, and effector-memory T-cells, signaling through the CCR7 receptor. It may play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. MIP-3ß specifically binds to chemokine receptor CCR7. MIP-3ß is strongly chemotactic for naive CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory CD4 T-cells. There is significant expression in dendritic cells in mesenteric and peripheral lymph nodes, and in spleen (T-cell zone or periarteriolar lymphatic sheath) and Peyer patches, but low expression in thymus. Recombinant mouse MIP-3-beta is a polypeptide chain consisting of 83 amino acids with a molecular weight of 9,200 Daltons.
序列
该MIP-3ß Mouse Recombinant Protein - 010-001-C21的详细信息查看Rockland提供的产品说明书。
来源宿主
Other - E.coli
溶解建议
Restore with deionized water (or equivalent)
保存建议
Store vial at 4° C prior to restoration. Dilute only prior to immediate use. Maintain sterility. This product DOES NOT contain preservative. DO NOT VORTEX. We recommend adding a carrier protein such as HSA or BSA to 0.1% (i.e. 1.0 mg/mL) . For best results aliquot contents and freeze at -20° C or colder. Avoid cycles of freezing and thawing. Centrifuge vial before each opening to dislodge contents from the cap and to clarify if contents are not clear after standing at room temperature.
