PARP1 is the primary member of the poly(ADP-ribose) polymerase family, whose function is to signal DNA damage (and to recruit repair proteins) by PARylation. PARP1 is also involved in multiple cell death pathways, including apoptosis, necroptosis, autophagy, and a relatively new pathway termed parthanatos. PARP1 can also promote tissue survival by shifting the balance of cell death programs between autophagy and necrosis. Clinical studies have shown vulnerability to PARP inhibitors in DNA repair defective cancers. PARP1-AD is useful for researchers interested in cellular processes including DNA damage, transcriptional control, and stem cell identity research.
序列
该【干冰】PARP1 (internal) Control Protein - 009-001-X51的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】PARP1 (internal) Control Protein - 009-001-X51的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】PARP1 (internal) Control Protein - 009-001-X51的详细信息查看Rockland提供的产品说明书。
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable 2 - 3 weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
