神经生化标志物S100B ELISA试剂盒，检测灵敏度更高！

       什么是S100B？
       S100家族蛋白是一组低分子量的钙结合蛋白，因其可溶解在pH值为7.0的饱和硫酸铵溶液中，故命名为S100蛋白，由α和β两种亚基组成，形成同型或者异型二聚体，主要分为三个亚型：S100A0（αα）、S100A(αβ) 和 S100B(ββ)。不同S100蛋白亚型在人体的表达分布具有相对特异性，其中S100A0主要存在于神经元细胞中；S100A主要存在于横纹肌、心肌和肾脏；S100B主要分布于中枢神经系统和周围神经系统的神经胶质细胞和Schwann细胞以及某些神经元细胞、黑色素细胞、软骨细胞和脂肪细胞中。
S100B是目前在恶性黑色素瘤中应用最广泛的生物标志分子，特别是转移性黑色素瘤，S100B水平的升高与预后相关，升高的血清S100B水平强烈提示预后不良。亦有报道称，血清标志物 S100B 检测可准确识别肺癌脑转移。

Abnova艾美捷全国代理商热线

       有没有可以检测S100B含量的试剂盒呢？
       艾美捷科技为您推荐享誉全球市场的S100B定量分析试剂盒： KA0037

       原理：该S100B定量分析试剂盒利用双抗夹心法，在96孔板中预包被了人S100B蛋白的捕获抗体，将标准品，质控品，以及样品加入到96孔板中孵育结合，经过洗涤，再加入生物素标记的S100B检测抗体，通过链霉亲和素-HRP系统结合再次放大信号，HRP与底物反应产生有色产物。吸光值越高，对应样品中S100B含量越多。

       S100B ELISA试剂盒Tips：
       »适用样品：脊髓液（CSF），血清，肝素血浆（EDTA和柠檬酸钠血浆，不能用于该试剂盒）
       »检测范围：10 to 320 pg/mL

《 S100B ELISA试剂盒标准曲线 》

 
       S100B ELISA试剂盒已发布众多文章：
       1.BET bromodomain inhibitors synergize with ATR inhibitors in melanoma in melanoma.
Muralidharan SV, Einarsdottir BO, Bhadury J, Lindberg MF, Wu J, Campeau E, Bagge RO, Stierner U, Ny L, Nilsson LM, Nilsson JA.Cell Death Dis. 2017 Aug 10;8(8):e2982.
       2.S100B promotes injury-induced vascular remodeling through modulating smooth muscle phenotype.
Cao T, Zhang L, Yao LL, Zheng F, Wang L, Yang JY, Guo LY, Li XY, Yan YW, Pan YM, Jiang M, Chen L, Tang JM, Chen SY, Jia-NingWang.Biochim Biophys Acta. 2017 Jul 7. [Epub ahead of print]
       3.Inflammation and vascular remodeling in the ventral hippocampus contributes to vulnerability to stress.
Pearson-Leary J, Eacret D, Chen R, Takano H, Nicholas B, Bhatnagar S.Transl Psychiatry. 2017 Jun 27;7(6):e1160.
       4.Fast therapeutic hypothermia prevents post-cardiac arrest syndrome through cyclophilin D-mediated mitochondrial permeability transition inhibition.
Jahandiez V, Cour M, Bochaton T, Abrial M, Loufouat J, Gharib A, Varennes A, Ovize M, Argaud L.Basic Res Cardiol. 2017 Jul;112(4):35. doi: 10.1007/s00395-017-0624-3. Epub 2017 May 10.
       5.Effect of Exercise Intensity on Neurotrophic Factors and Blood-Brain Barrier Permeability Induced by Oxidative-Nitrosative Stress in Male College Students.
Roh HT, Cho SY, Yoon HG, So WY.Int J Sport Nutr Exerc Metab. 2016 Dec 20:1-23.
       6.Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions.
Mothapo KM, Ten Oever J, Koopmans P, Stelma FF, Burm S, Bajramovic J, Verbeek MM, Rikkert MG, Netea MG, Koopman G, van der Ven AJJ Neurovirol. 2016 Nov 23. [Epub ahead of print]
       7.The effects of aerobic exercise training on oxidant-antioxidant balance, neurotrophic factor levels, and blood-brain barrier function in obese and nonobese men.
Roh HT,So WYJournal of Sport and Health Science. 2016 Jul 18
       8.Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise.
Roh H, Cho S, So W.Journal of Sport and Health Science. 2016 Jun 27. [Epub ahead of print]
       9.Cognitive Function and Oxidative Stress After Carotid Endarterectomy: Comparison of Propofol to Sevoflurane Anesthesia.
Kalimeris K, Kouni S, Kostopanagiotou G, Nomikos T, Fragopoulou E, Kakisis J, Vasdekis S, Matsota P, Pandazi AJ Cardiothorac Vasc Anesth. 2013 May 29. pii: S1053-0770(12)00640-4. doi: 10.1053/j.jvca.2012.12.009.
       10.The prognostic significance of the serum biomarker H-FABP in comparison with S100b in severe traumatic brain injury.
Walder B, Robin X, Rebetez MM, Copin JC, Gasche Y, Sanchez JC, Turck NJ Neurotrauma. 2013 Apr 16.
       11.Induction of Oxidative and Nitrosative damage leads to Cerebrovascular Inflammation in Animal Model of Mild Traumatic Brain Injury Induced by Primary Blast.
Abdul-Muneer PM, Schuetz H, Wang F, Skotak M, Jones J, Gorantla S, Zimmerman MC, Chandra N, Haorah JFree Radic Biol Med. 2013 Mar 2. pii: S0891-5849(13)00093-2. doi: 10.1016/j.freeradbiomed.2013.02.029.
       12.Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: A randomized controlled trial.
Jones BO, Pepe S, Sheeran FL, Donath S, Hardy P, Shekerdemian L, Penny DJ, McKenzie I, Horton S, Brizard CPJ Thorac Cardiovasc Surg. 2013 Feb 13. pii: S0022-5223(13)00026-3. doi: 10.1016/j.jtcvs.2013.01.003.
13.Marked Increase of the Astrocytic Marker S100B in the Cerebrospinal Fluid of HIV-infected Patients on LPV/r-Monotherapy.
Pasquier RA, Jilek S, Kalubi M, Yerly S, Fux CA, Gutmann C, Cusini A, Gunthard HF, Cavassini M, Vernazza PL; the Swiss HIV Cohort Study.AIDS. 2012 Oct 1. [Epub ahead of print]
       14.S100B: Role in cardiac remodeling and function following myocardial infarction in diabetes.
Mohammadzadeh F, Desjardins JF, Tsoporis JN, Proteau G, Leong-Poi H, Parker TG.Life Sci. 2012 Sep 20. pii: S0024-3205(12)00510-3. doi: 10.1016/j.lfs.2012.09.011. [Epub ahead of print]
       15.Plasma heart-type fatty acid binding protein level in acute ischemic stroke: Comparative analysis with plasma S100B level for diagnosis of stroke and prediction of long-term clinical outcome.
Park SY, Kim MH, Kim OJ, Ahn HJ, Song JY, Jeong JY, Oh SH.Clin Neurol Neurosurg. 2012 Jul 3.
Hyperglycaemia-induced pro-inflammatory responses by retinal Muller glia are regulated by the receptor for advanced glycation end-products (RAGE).
Zong H, Ward M, Madden A, Yong PH, Limb GA, Curtis TM, Stitt AW.Diabetologia. 2010 Sep 12. [Epub ahead of print]
       16.Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags.
Dayon L, Hainard A, Licker V, Turck N, Kuhn K, Hochstrasser DF, Burkhard PR, Sanchez JC.Anal Chem. 2008 Apr 15;80(8):2921-31. Epub 2008 Mar 1.

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