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100+篇文章引用,超经典RIP3抗体(PSI-2283)

发布者:艾美捷科技    发布时间:2023-12-01     
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RIP3 / RIPK3抗体

RIP3(RIPK3,Receptor Interacting Protein 3),受体相互作用蛋白3,是一种重要的蛋白质,在细胞凋亡过程中起着关键作用。近年来,RIP3蛋白研究取得了显著进展。首先,研究人员发现RIP3蛋白与许多其他重要的蛋白质相互作用,从而参与了细胞凋亡的诱导和调节。其中,一些研究表明RIP3蛋白与蛋白质复合物Necrosome相关,这是一个重要的细胞凋亡诱导机制。此外,RIP3蛋白也与细胞凋亡调节因子、蛋白酶以及其他蛋白质相互作用,参与了细胞凋亡的诱导和调节。随着新病毒如SARS-CoV-2的出现以及流感、MPOX和RSV等已知病毒的激增,RIPK 3已成为研究和治疗的首要靶点,但最近的研究表明,它是几种炎症性疾病、退行性疾病甚至癌症的可行靶点。   


艾美捷科技为您推荐ProSci,经敲除验证的RIP3 / RIPK3抗体(货号PSI-2283),已被广泛引用,在抗体引文跟踪器CiteAb上被引用多达171次,在Bioz上被引用多达165次。我们抗体的可靠性促成了它的受欢迎程度,在许多顶级期刊上发表的研究中,包括《Nature》《Cell》《Nature Medicine》。至关重要的是,我们的抗体已经参与了很多与治疗学开发相关的研究,以及冠状病毒和COVID-19疗法有关的研究。  


RIP3 / RIPK3抗体


抗体名称RIP3 抗体
货号PSI-2283
克隆性多克隆
应用类型E, IF, IHC-P, IP, WB
宿主来源
反应种属人类、小鼠、大鼠


ProSci抗体


以下几篇文章展示了在您的研究中使用ProSci抗体的疗效:

  • Karki R, Lee S, Mall R, et al. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection. Sci Immunol. 2022;7(74):eabo6294. doi:10.1126/sciimmunol.abo6294

  • Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti TD. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature. 2021;597(7876):415-419. doi:10.1038/s41586-021-03875-8

  • Zhang T, Yin C, Boyd DF, et al. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Cell. 2020;180(6):1115-1129.e13. doi:10.1016/j.cell.2020.02.050

  • Zheng M, Karki R, Vogel P, Kanneganti TD. Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. Cell. 2020;181(3):674-687.e13. doi:10.1016/j.cell.2020.03.040


RIP3 / RIPK3抗体相关产品推荐:

  • RIPK1 ,货号:PSI--5389(50篇以上文章)

  • MLKL ,货号:PSI--14-026

  • TRIF ,货号:PSI--3173(50篇以上文章)

  • FADD ,货号:PSI--18-232, 18-273 (KO Validated)

  • cFLIP ,货号:PSI--1159(50篇以上文章)

  • NLRP3 ,货号:PSI--5447(50篇以上文章)

  • NOD2 ,货号:PSI--2513(50篇以上文章)

  • Caspase8 ,货号:PSI--3473(50篇以上文章)


RIP3 / RIPK3抗体更多发表文章:

  • He et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 2009;137(6):1100-11. PMID: 19524512

  • Zhang et al. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature. 2011;471(7338):373-6. PMID: 21368761

  • Narayan et al. The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature. 2012;492(7428):199-204. PMID:   23201684

  • Li et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016;23(9):1428-47. doi:10.1038/cdd.2016.21. Epub 2016. PMID:        26943325

  • Yang et al. Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis. Cell Death Dis. 2017;8(10):e3084. doi:10.1038/cddis.2017.483. PMID: 28981102

  • Ramachandran et al. Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology. 2013;58(6):2099-108. PMID: 23744808

  • Li et al. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 2012 ;150(2):339-50. PMID:        22817896

  • Vitner et al. RIPK3 as a potential therapeutic target for Gaucher's disease. Nat Med. 2014;20(2):204-8. PMID: 24441827

  • Wang et al. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014;15(12):1126-33. PMID: 25326752

  • Onizawa et al. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 2015;16(6):618-27. PMID: 25939025

  • Murphy et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity. 2013;39(3):443-53. PMID: 24012422

  • Nogusa et al. RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Cell Host Microbe 2016;20(1):13-24. PMID: 27321907

  • Pearson et al. EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation. Nat Microbiol. 2017 ;2:16258. PMID: 28085133

  • Yang et al. The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity? Hepatology. 2016;64(1):311-2PMID: 26418225

  • Qu et al. Graphene oxide induces toll-like receptor 4 (TLR4)-dependent necrosisin macrophages. ACS Nano. 2013;7(7):5732-45.PMID: 23734789

  • Gandhirajan et al. Blockade of NOX2 and STIM1 signaling limits Lipo polysaccharide-induced vascular inflammation. J Clin Invest. 2013;123(2):887-902. PMID: 23348743

  • Fortes et al. Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood. 2012;119(10):2368-75. PMID: 22262768

  • Xu et al. The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited. Nat Commun. 2017;8(1):425. PMID: 28871172

  • Karunakaran et al. Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis. Sci Adv. 2016 ;2(7):e1600224. PMID: 27532042

  • Chen et al. Mechanisms of necroptosis in T cells. J Exp Med. 2011 Apr 11;208(4):633-41.PMID: 21402742


ProSci Incorporated于1998年成立于美国加州圣地亚哥市,从事抗体等科研试剂的研发、生产和销售。产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。ProSci拥有超过30000种单克隆抗体和多克隆抗体。ProSci的抗体大都经免疫亲和层析纯化,具有高纯度、高亲和力、特异性强等特点,所有的ProSci抗体都经过了严格的验证测试和质量控制,已保证高质量的产品。此外,ProSci还提供标记二抗,重组蛋白,细胞和组织裂解液,细胞涂片,组织切片,多肽等产品与抗体配套使用。


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