Montana Molecular-PIP2检测试剂盒：低毒性，实时动态读数

Montana Molecular-PIP2检测试剂盒的性能：

基因编码，低毒性

PIP2传感器和对照组包含在BSL-1级的BacMam载体中，可在多种细胞中有效表达

单通道读数可以与额外的GPCR检测结合使用

实时动态读数

多重检测试验：

结合红色和绿色传感器，可以同时测量多个GPCR信号通路

艾美捷 Montana Molecular-PIP2检测试剂盒简单的操作流程：

无需细胞裂解

单通道读数

BSL-1级载体

控制表达水平

Montana Molecular-PIP2检测试剂盒文献参考：

L. Brueggemann, et al. Structural Determinants of Kv7.5 Potassium Channels that Confer Changes in Phosphatidylinositol 4,5-Biphosphate (PIP2) Affinity and Signaling Sensitivity in Smooth Muscle Cells. Molecular Pharmacology. March 2020.

L.Liu, et al. Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation. J.Neurosci. May 2019.

Alexey N. Pronin, Qiang Wang and Vladlen Z. Slepak Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor Molecular Pharmacology Nov. 2018

Y. Ding, et al. Ratiometric biosensors based on dimerization dependent fluorescent protein exchange. Nature Methods, 2015.

P. Tewson, et al. A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells. J. Biomolecular Screening 18, 2013.

Montana Molecular产品主要包括GPCR检测、细胞应激和毒性相关检测工具，为客户提供了长时间内观察候选药物对细胞过程影响的能力。艾美捷科技是Montana Molecular的中国代理商，为科研工作者提供优质的产品与服务。