中英文说明书丨Athens Research人血浆转铁蛋白

Transferrin is a monomeric glycoprotein found in plasma at an average concentration of 250 mg/100 ml. The specific iron-binding protein in plasma, it has a role in the transportation and distribution of iron among the body organs, in iron metabolism and prevention of iron loss via the kidneys. Stored in bone marrow as Tf-bound iron, it also possesses bacteriostatic and fungistatic activity. Clinically, decreases in transferrin are observed in congenital disorders, newborns, inflammatory diseases, hypoproteinemias and nephrotic syndrome; increases are found in pregnancy, iron-deficiency anemias, and inoculation hepatitis. Transferrin is required by all types of cells in cultures for maximal growth. It is, therefore, an important transport factor used in defined culture media.

Synonym: Human transferrin, Siderophilin

Storage: <= -20°C

Purity: >=95% by SDS-PAGE

Iron Content: >= 1100 ug per gram

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Citations:

Enns, Caroline A., Riffat Ahmed, Jiaohong Wang, Akiko Ueno, Christal Worthen, Hidekazu Tsukamoto, and An-Sheng Zhang. "Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway." PloS one 8, no. 4 (2013): e60534.

Ref:

MacGillivray, R.T.A. et al. 1982 Proc. Natl. Acad. Sci. USA. 79,2504; Rivat,C. et al. 1992 J. Chromatogr. 576,71

转铁蛋白是一种单体糖蛋白，存在于血浆中，平均浓度为250mg/100ml。血浆中的特异性铁结合蛋白，在铁在身体器官之间的运输和分布、铁代谢和预防肾脏铁流失方面发挥作用。它以Tf结合铁的形式储存在骨髓中，还具有抑菌和抑菌活性。临床上，先天性疾病、新生儿、炎症性疾病、低蛋白血症和肾病综合征中观察到转铁蛋白的减少；妊娠、缺铁性贫血和接种肝炎的发病率都有所增加。培养物中所有类型的细胞都需要转铁蛋白才能最大限度地生长。因此，它是特定培养基中使用的重要运输因素。

艾美捷人血浆转铁蛋白基本信息：

货号：16-16-032001

同义词：人转铁蛋白、侧营养因子

储存条件：≤ -20°C

纯度：≥95%（通过SDS-PAGE测定）

铁含量：≥每克1100微克

经FDA要求的检测，显示用于制备的血浆对HBsAg、抗-HCV、抗-HBc无反应，并且抗-HIV 1 & 2呈阴性。

不得用于人体或任何药物用途。仅限研究使用。

SDS-PAGE：

4-12%Bis-Tris-NuPAGE凝胶

低分子量标准

转铁蛋白 - 5 微克（非还原条件/无需加热）

转铁蛋白 - 10 微克（非还原条件/无需加热）

转铁蛋白 - 20 微克（非还原条件/无需加热）

人血浆转铁蛋白文献参考：

MacGillivray, R.T.A. et al. 1982 Proc. Natl. Acad. Sci. USA. 79,2504; Rivat,C. et al. 1992 J. Chromatogr. 576,71  

Athens Research & Technology 的人血浆转铁蛋白都能发挥关键作用。对于从事细胞生物学研究的科学家来说，它是优化细胞培养条件的得力助手。在血液学和免疫学领域，有助于深入了解铁代谢与免疫系统之间的微妙关系。而在肿瘤研究中，转铁蛋白的异常表达和功能失调往往与肿瘤的发生、发展和转移密切相关。