Click Chemistry Tools/艾美捷DBCO-PEG4-NHS酯特异性且高效方案

DBCO-PEG4-NHS酯在pH 7-9的条件下能特异性且高效地与一级胺（例如，赖氨酸残基的侧链或氨基硅烷包覆的表面）反应形成共价键。亲水性的聚乙二醇（PEG）间隔臂赋予了水溶性，并提供了一个长而灵活的连接，这极小化了与含有叠氮的互补分子连接时的立体阻碍。

艾美捷Click Chemistry Tools DBCO-PEG4-NHS酯 #CCT-A134规格：

单位规格 10毫克，4×2毫克，25毫克，100毫克，500毫克

分子量 649.68

化学成分 C34H39N3O10

CAS号 1427004-19-0

溶解性 DMSO、DMF、二氯甲烷（DCM）、四氢呋喃（THF）、氯仿

纯度 >95%（高效液相色谱法，HPLC）

外观 黄色至微橙色油状物

储存条件 -20摄氏度。保持干燥

运输条件 常温

Click Chemistry Tools DBCO-PEG4-NHS酯文献参考：

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Ahn, S.H., et al. (2020). Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid. Bioconjugate Chem., 31(4), 1177-87. [PubMed]

Pack, J., et al. (2020). Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles. Bioconjugate Chem., 31(5), 1408-16. [PubMed]

Miller, A. L., et al. (2019). Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery?. Polym. Chem., 10, 705-717. [Publishing]

Huynh, V., et al. (2018). Competitive Affinity Release for Long-Term Delivery of Antibodies from Hydrogels. Bioconjugate Chem., 57(13), 3406-10. [PubMed]

Nedrow-Byerst, J.R., et al. (2013). PSMA-targeted SPECT agents: mode of binding effect on in vitro performance. Prostate., 73(4), 355-62. [PubMed]

Click Chemistry Tools（CCT）一直致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。目前CCT的产品线主要包括：Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。艾美捷科技是Click Chemistry Tools（CCT）的中国代理商，为科研工作者提供优质的产品与服务。