SCREEN-WELL生物活性脂质库，筛选或鉴定重组孤儿 G 蛋白偶联受体

SCREEN-WELL生物活性脂质库包含 190 种 96 孔格式的生物活性脂质。非常适合筛选或鉴定重组孤儿 G 蛋白偶联受体、靶标验证、二次筛选、验证新测定和常规药理学应用。

内容： 190种化合物，包括：激动剂和拮抗剂，内源性大麻素，法呢基/香叶基香叶基衍生物，HETEs deHETEs，七氧西林，多不饱和脂肪酸，白三烯，脂氧素，LPA和磷脂酸，十八烷类，PAF，前列腺素和血栓素，类维生素A，维生素D代谢物，鞘脂。

数量： 每孔100或500μl。

浓度： DMSO溶液（1.0或0.1mM，取决于化合物）。

使用/稳定性：在-80°C下储存时，自收到之日起至少可稳定一年。

航运： 干冰

长期储存：-80°C

RUO - 仅供研究使用

艾美捷SCREEN-WELL生物活性脂质库#BML-2800-0100相关参数说明：

The SCREEN-WELL  Bioactive Lipid Library contains 190 bioactive lipids in a 96 well format. Ideal for screening or identifiying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays and for routine pharmacological applications.

Applications: HTS

Contents: 190 compounds including: Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids.

Quantity: 100 or 500?l per well.

Concentration: DMSO solutions (1.0 or 0.1mM, depending on compound).

Use/Stability: Stable for at least one year from the date of receipt when stored at -80°C.

Long Term Storage: -80°C

SCREEN-WELL生物活性脂质库部分文献参考：

1.Molecular basis for the interaction of cellular retinol-binding protein 2 (CRBP2) with non-retinoid ligands: J. Silvaroli, et al.; J. Lipid Res. 62, 100054 (2021),

2.Mechanism of activation for the sirtuin 6 protein deacylase: M.A. Klein, et al.; J. Biol. Chem. 295, 1385 (2020),

3.Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1: J.A. Silvaroli, et al.; ACS Chem. Biol. 14, 434 (2019),

4.Brown Adipogenic Reprogramming Induced by a Small Molecule: B. Nie, et al.; Cell Rep. 18, 624 (2017),

5.Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest. 127, 2739 (2017),

6.AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells: T. Yoshinaga, et al.; PLoS One 11, e0167848 (2016),

7.Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells: J.H. Rhim, et al.; Sci. Rep. 6, 26547 (2016),

8.Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans: P.R. Rodrigues, et al.; G3 (Bethesda) 6, 1695 (2016),

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