V65单克隆抗体与大鼠γ/δTCR(γδT细胞受体)反应。γ/δTCR由胸腺、外周淋巴组织、肠上皮、表皮和腹膜中发现的T细胞亚群表达。表达γ/δTCR的T细胞的确切功能、配体和特异性尚不完全清楚。研究表明,这些细胞在MHC I类基因产物的背景下识别细菌配体和一些肿瘤细胞,并在细菌感染期间调节免疫反应中发挥作用。
艾美捷InVivoMAb抗鼠TCRγ/δ/InVivoMAb anti-rat TCR γ/δ:
货号:BE0414
同型:小鼠IgG1,κ
推荐同型对照:InVivoMAb小鼠IgG1同型对照,未知特异性
推荐稀释缓冲液:InVivoPure pH 7.0稀释缓冲液
偶联:未偶联。可通过BioXCell的抗体偶联服务进行偶联。
免疫原:大鼠T细胞母细胞
报告应用:体内γ/δ T细胞耗竭
流式细胞术
配方:PBS,pH 7.0
不含稳定剂或防腐剂
内毒素:<2EU/mg(<0.002EU/μg)
由LAL凝胶凝集试验确定
纯度:>95%
由SDS-PAGE确定
无菌性:0.2微米过滤
生产:在无动物设施中从细胞培养上清液中纯化
纯化:蛋白G
分子量:150 kDa
储存:抗体溶液应以原液浓度在4°C下储存。不要冷冻。
InVivoMAb抗鼠TCRγ/δ/InVivoMAb anti-rat TCR γ/δ文献引用:
Flow Cytometry
Ando T, Wu H, Watson D, Hirano T, Hirakata H, Fujishima M, Knight JF. (2001). "Infiltration of canonical Vgamma4/Vdelta1 gammadelta T cells in an adriamycin-induced progressive renal failure model" J Immunol 167(7):3740-5.
in vivo γ/δ T cell depletion
Jansson AM, Lorentzen JC, Bucht A. (2000). "CD8+ cells suppress oil-induced arthritis" Clin Exp Immunol 120(3):532-6.
Flow Cytometry
Knudsen E, Seierstad T, Vaage JT, Naper C, Benestad HB, Rolstad B, Maghazachi AA. (1997). "Cloning, functional activities and in vivo tissue distribution of rat NKR-P1+ TCR alpha beta + cells" Int Immunol 9(7):1043-51.
Kühnlein P, Park JH, Herrmann T, Elbe A, Hünig T. (1994). "Identification and characterization of rat gamma/delta T lymphocytes in peripheral lymphoid organs, small intestine, and skin with a monoclonal antibody to a constant determinant of the gamma/delta T cell receptor" J Immunol 153(3):979-86.
微信扫码在线客服