LDN Labor Diagnostika Nord-SHBG ELISA (RUO) Kit:血清或血浆中性激素结合球蛋白(SHBG)的酶免疫测定。
艾美捷LDN Labor Diagnostika Nord-SHBG ELISA (RUO) Kit(AA E-1200R):
名称:SHBG ELISA
描述:
用于血清或血浆中性激素结合球蛋白(SHBG)定量测量的酶免疫测定法。
设计:ELISA
样本体积:
50微升预稀释的血清或血浆
总检测时间:2小时45分钟
标准范围:0/4 – 260纳摩尔/升
灵敏度:0.408纳摩尔/升
储存条件:2 – 8°C
试剂盒:96次测定
CE认证:是
LDN Labor Diagnostika Nord-SHBG ELISA (RUO) Kit检测原理:
性激素结合球蛋白(SHBG)是一种95kD的同源二聚体糖蛋白,在肝脏中合成,在血浆中的半衰期为7天。SHBG以高亲和力特异性结合类固醇激素(DHT>睾酮-雌二醇;DHEA/雄烯二酮/雌三醇),其主要功能是性类固醇在血流内和血管外靶组织中的转运。SHBG还通过性类固醇对可用结合位点的竞争和SHBG浓度的波动,在调节生物可利用性类固醇浓度方面发挥关键作用。血液中SHBG浓度表现出高度的个体间变异性,并受雄激素/雌激素平衡、营养状况、体重指数、性别、胰岛素浓度等因素的影响。
LDN Labor Diagnostika Nord-SHBG ELISA (RUO) Kit参考文献:
1. Moore, JW and Bulbrook RD. The epidemiology and function of sex hormone binding globulin.IN Oxford Rewievs of Reproductive Biology, 1988; 10: 180 - 236.
2. Selby, C. Sex hormone binding globulin: origin, function and clinical significance.Ann. Clin. Biochem. 1990; 27: 532 - 541.
3. Tehernof A, Despres JP: Sex steroid hormone, sex hormone-binding globulin, and obesity in men andwomen.Horm. Metab. Res.2000; 32:526-536.
4. Kahn SM, Hryb DJ, Nakhle AM, Romas NA: Sex hormone-binding globulin is synthesized in target cells.J Endocrinol 2002; 175:113-120.
5. Hammond GL: Access of reproductive steroids to target issues.Obstet Gynecol Clin North Am 2002; 29:411-423.
6. 5. Elmlinger MW, Kuhnel W, Ranke MB: Reference ranges for serum concentrations of lutropin (LH),follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone binding globulin (SHBG),dehydroepiandrosterone sulfate (DHEA-S), cortisol and ferritin in neonates, children, and young adults.Clin Chem Lab Med 2002; 40(11):1151-1160.
7. Deswal ., Yadav A, Dang AS Sex hormone binding globulin - an important biomarker for predictingPCOS risk: A systematic review and meta-analysis.Syst Biol Reprod Med 2018; 64: 12-24.
8. Sanches de Melo et al. Hormonal contraception in women with polycystic ovary syndrome: choices,challenges, and noncontraceptive benefits.Open Access J Contracept.2017; 2;8:13-23.
LDN Labor Diagnostika Nord GmbH & Co. KG(简称LDN)旨在开发、制造和向临床和研究实验室市场提供专业的体外诊断测试系统和创新技术。艾美捷科技是LDN Labor Diagnostika Nord的中国代理商,为科研工作者提供优质的产品与服务。
微信扫码在线客服