Bertin Bioreagent 血管紧张素II SPIE-IA试剂盒在免疫治疗研究中的潜在作用

肾素-血管紧张素系统对于控制血压至关重要。在血管紧张素原蛋白水解加工产生的不同肽中，八肽血管紧张素 II （AII） 是参与高血压疾病病理生理学的主要激素，因为它介导血管收缩作用。它是允许正确估计肾素-血管紧张素系统的首选靶标。

作为Bertin Bioreagent全国总代理，艾美捷科技强烈推荐Bertin Bioreagent热销产品血管紧张素II SPIE-IA试剂盒。产品仅用于科研，不可用于临床诊断。

血管紧张素II SPIE-IA试剂盒：

文献参考：

PRODUCT EXPLANATION: ACETYLCHOLINESTERASE MARKER IN ENZYME-IMMUNOASSAYS

Grassi J., Pradelles P. Compounds labelled by the acetylcholinesterase of Electrophorus Electricus. Its preparation process and its use as a tracer or marquer in enzymo-immunological determinations. United States patent, N° 1,047,330. September 10, 1991

Grassi J., Pradelles P. The use of Acetylcholinesterase as a Universal marker in Enzyme-Immunoassays. Proceedings of the Third International Meeting on Cholinesterases, American Chemical Society (1991)

Pradelles P., Grassi J., Maclouf J. Enzyme Immunoassays of Eicosanoids Using Acetylcholinesterase. Methods in Enzymology (1990), vol. 187, 24-34

PRODUCT EXPLANATION: ANGIOTENSIN II

Paulis L, Unger T. Novel therapeutic targets for hypertension Nat Rev Cardiol. 2010 Aug;7(8):431-41

PRODUCT EXPLANATION: KIT DEVELOPMENT

Volland H, Pradelles P, Ronco P, Azizi M, Simon D, Créminon C, Grassi J. A solid-phase immobilized epitope immunoassay (SPIE-IA) permitting very sensitive and specific measurement of angiotensin II in plasma. J Immunol Methods. 1999 Aug 31;228(1-2):37-47

Pradelles Ph. Immunometric determination of an antigen or hapten. United states patent, N°5,476,770. December 19; 1995

Kohara K, Tabuchi Y, Senanayake P, Brosnihan KB, Ferrario CM. Reassessment of plasma angiotensins measurement: effects of protease inhibitors and sample handling procedures. Peptides. 1991 Sep-Oct;12(5):1135-41

Grassi J, Créminon C, Frobert Y, Etienne E, Ezan E, Volland H, Pradelles P. Two different approaches for developing immunometric assays of haptens. Clin Chem. 1996 Sep;42(9):1532-6

Valentin MA, Ma S, Zhao A, Legay F, Avrameas A. Validation of immunoassay for protein biomarkers: Bioanalytical study plan implementation to support pre-clinical and clinical studies. J Pharm Biomed Anal. (2011) 55(5): 869-877

European Medicines Agency. Guideline on bioanalytical method validation, 21 July 2011

法国Bertin Technologies公司是一家大型仪器设备及试剂供应商，拥有50多年的历史，产品涉及卫生、环境、安全甚至军工等诸多领域。Bertin Bioreagent是Bertin Technologies集团的生物试剂部门，主要是致力于研发与炎症，氧化损伤，内分泌学，糖尿病，肥胖症，高血压，精神药理学，癌症，哮喘，朊病毒疾病，药代动力学和代谢等相关的化学试剂 ，蛋白，底物，抗体及检测试剂盒等产品。 Bertin Instruments是Bertin Technologies集团的仪器部门，其中旗舰产品Precellys系列多功能生物样品匀浆器是全世界各个实验室的明星产品，截至目前累计有15000+的引文！ 作为Bertin在中国的区域总代理，艾美捷科技有限公司将为中国客户提供全面的Bertin的产品。