BioVendor：Club cell protein检测试剂盒

发布者：艾美捷科技发布时间：2022-07-29

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Human Club cell protein（CC16、CC10、子宫珠蛋白、尿蛋白1或克拉拉细胞分泌）是分泌珠蛋白家族的成员，是非连接的分泌产物。细支气管Clara细胞，它的功能还有待充分阐明，但令人信服的数据表明其作为免疫调节剂和抗炎剂的作用。Club cell protein抑制磷脂酶A2活性以及干扰素γ信号传导和Th1与Th2淋巴细胞调节。血清、血浆和支气管肺泡灌洗液中的Clara细胞蛋白浓度测定。

自1994年以来在众多研究中使用的洗液。在血清中，它的增加与年龄和石棉、氯化氮和臭氧暴露。更高水平的CC16在结节病、肺纤维化和高PEEP通气患者。血清减少在吸烟者和慢性病患者的肺切除术后发现CC16水平。阻塞性肺病、哮喘或二氧化硅暴露。患此病的胎儿羊水中也发现CC16浓度降低。各种机制引起的肺发育不良（膈疝、糖尿病）嗜好、特纳和唐氏综合征）。在胸腔积液中，CC16浓度出现。与肺中CC16高水平的扩散有关。胸膜充血。基于以上报道，Club cell protein可能是肺部疾病和损伤有前景的诊断标志物。

今天给大家带来了艾美捷代理品牌BioVendor公司的一款备受好评的Club cell protein检测试剂盒：

货号	产品名称	规格
RD191022200	Club Cell Protein (CC16) Human ELISA 人Clara细胞蛋白(CC16)Elisa 试剂盒	96 wells(1 kit)

以上产品仅用于科研，不能用于医疗诊断~

检测步骤：

检测步骤

检测范围和灵敏度：

指标	检测范围	灵敏度
CC16	1.57–50 ng/ml	46 pg/ml

精确度：

组内差异（n=8）

Sample	Mean (ng/ml)	SD (ng/ml)	CV (%)
1	14.28	0.55	3.82
2	5.31	0.16	2.96

组间差异（n=4）

Sample	Mean (ng/ml)	SD (ng/ml)	CV (%)
1	5,37	0.22	4.09
2	7.75	0.49	6.36
3	16.59	0.63	3.78

不同体液样本中CC16的典型浓度：

样本类型	平均值 (ng/ml)	范围 (ng/ml)
血清	12.6	3.7 – 23.2
尿液	18.7	0.2 – 88.6
精液	1 030.0	145 – 8 600
BAL	1 360.0	154 – 4 300
滑液	9.1	2.8 – 16.4
胸膜液	11.4	0.7 – 32.8
脑脊液	0.5	0 – 5.7
胃液	185.0	0 – 1 220
胆汁	0.7	0 – 2.3

详情参见：

Shijubo N., Kawabata I., Sato N., Itoh Y.: Clinical Aspects of Clara Cell 10-kDa Protein/ Uteroglobin (Secretoglobin 1A1), Current Pharmaceutical Design, 9, 1139-1149, (2003)

标准曲线：

标准曲线

引文汇总：

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