Relia Tech：活性VEGF，VEGFR重组蛋白

新血管的形成(angiogenesis)是肿瘤生长转移和传播过程中的一种基本活动。因此，在癌症研究领域,人们对研究肿瘤血管生成的分子机制十分感兴趣。而血管内皮生长因子(vascular endothelial growth factor,VEGF)路径是这一过程的关键调节者。   

VEGF(vascular endothelial growth factor，血管内皮生长因子)/VEGFR(vascular endothelial growth factor receptor，血管内皮生长因子受体)轴由多重配基和受体质量叠加交错组成，并且受体与配基结合具有专一性，在不同的细胞中具有不同的细胞类型表达和功能，启动VEGFR信号通路，触发了一个网状的信号过程，从而促进血管内皮细胞生长、转移和存活。VEGF/VEGFR也是目前研究最多的一条信号通路，并取得了显著的成果。

作为专业的生命科学医药原料和解决方案供应商，艾美捷科技为您推荐来自德国，Relia Tech荣誉出品：活性VEGF，VEGFR重组蛋白 

* 以上蛋白产品，均为冻干粉形式.* 蛋白分子量与序列详情，欢迎垂询艾美捷客服. 

VEGF蛋白 SDS-PAGE	VEGF蛋白刺激HUVEC增殖

  【VEGF/VEGFR产品发表文章】

• Cudmore, M., Hewett, P., Ahmad, S. et al. The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis. Nat Commun 3, 972 (2012). https://doi.org/10.1038/ncomms1977

• Teichert, M., Milde, L., Holm, A. et al. Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun 8, 16106 (2017). https://doi.org/10.1038/ncomms16106

• SUCNR1 Is Expressed in Human Placenta and Mediates Angiogenesis: Significance in Gestational Diabetes. R. Atallah et al., Int J Mol Sci. 2021 Nov; 22(21): 12048.

• Transforming growth factor‐β1 signalling triggers vascular endothelial growth factor resistance and monocyte dysfunction in type 2 diabetes mellitus. L.‐M. Makowski et al., J Cell Mol Med. 2021 Jun; 25(11): 5316–5325.

• Outgrowth, proliferation, viability, angiogenesis and phenotype of primary human endothelial cells in different purchasable endothelial culture media: feed wisely. B. Leopold et al., Histochem Cell Biol. 2019; 152(5): 377–390.

• Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury. Qi Chen et al., Cell Stem Cell. 2019 Dec 5; 25(6): 768–783.e6.

• BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation. E. Pardali et al., J Cell Mol Med. 2018 Nov;22(11):5429-5438.

• Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential.  Tasev D et al., Front Med (Lausanne). 2018 Dec 20;5:356.

• Blood Outgrowth and Proliferation of Endothelial Colony Forming Cells are Related to Markers of Disease Severity in Patients with Pulmonary Arterial Hypertension. Smits J et al., Int J Mol Sci. 2018 Nov 27;19(12). pii: E3763.

• Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. H. M. Eilken et al., Nat Commun. 2017; 8: 1574.

• CD34 expression modulates tube-forming capacity and barrier properties of peripheral blood-derived endothelial colony-forming cells (ECFCs). D. Tasev et al., Angiogenesis. 2016; 19: 325–338.

• Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature. Lohr J et al., Anticancer Res. 2015 May;35(5):2681-90.

• Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity. D. Tasev et al., PLoS One. 2015; 10(6): e0129935.

• The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib?). A. K.A. Gaumann et al., Int J Oncol. 2014 Dec; 45(6): 2267–2277.

• Improved Anchorage of Ti6Al4V Orthopaedic Bone Implants through Oligonucleotide Mediated Immobilization of BMP-2 in Osteoporotic Rats. J. V. W?lfle et al., PLoS One. 2014; 9(1): e86151.

• Spatial regulation of VEGF receptor endocytosis in angiogenesis. M. Nakayama et al., Nat Cell Biol.2 13 Mar; 15(3): 249–260.

• Fbxw7 Controls Angiogenesis by Regulating Endothelial Notch Activity. N. Izumi et al., PLoS One. 2012; 7(7): e41116.

• The Antiangiogenic 16K Prolactin Impairs Functional Tumor Neovascularization by Inhibiting Vessel Maturation. Ngoc-Quynh-Nhu Nguyen et al., PLoS One. 2011; 6(11): e27318.

• MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells. C. Sabatel et al., PLoS One. 2011; 6(2): e16979.

• Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis. S. Ahmad et al., Vasc Cell. 2011; 3: 15.

• Feed-forward Signaling by Membrane-bound Ligand Receptor Circuit: THE CASE OF NOTCH DELTA-LIKE 4 LIGAND IN ENDOTHELIAL CELLS. V. Caolo et al., J Biol Chem. 2010 Dec 24; 285(52): 40681–40689.

• Impaired Collateral Recruitment and Outward Remodeling in Experimental Diabetes. J. M. van Golde et al., Diabetes. 2008 Oct; 57(10): 2818–2823.

• Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. S. Ahmad and A. Ahmed Circ Res. 2004 Oct 29;95(9):884-91.

• Collagen type 1 retards tube formation by human microvascular endothelial cells in a fibrin matrix. Kroon, M.E. et al., Angiogenesis (2002) 5: 257.

德国重组蛋白品牌 ReliaTech ，ISO9001认证，低内毒素，90%以上的产品均有现货，每3周发货 ，快行业2周！  

热销：FGF2、a-mLYVE1、VEGF等活性重组蛋白【已发表文章超1000篇】，2800+细胞培养级低内毒素重组蛋白和抗体，专注受体与配体研究，适合用于VEGF靶向药物研发、生物制药原材料。 

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以上所有产品，均仅限于科研用途。不得用于医疗。

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