Kamiya:抗酒石酸酸性磷酸酶TRAP 染色试剂盒

       人类及动物体骨组织不断地进行着重建，骨重建过程包括骨的分解吸收与新骨的形成。破骨细胞（Osteoclast，OC）负责骨分解与吸收，而成骨细胞（osteoblast，OB）负责新骨形成。破骨细胞贴附在旧骨区域，分泌酸性物质溶解矿物质，分泌蛋白酶消化骨基质，形成骨吸收陷窝；其后，成骨细胞移行至被吸收部位，分泌骨基质，骨基质矿化而形成新骨。破骨与成骨过程的平衡是维持正常骨量的关键。   

       抗酒石酸酸性磷酸酶（TRAP，tartrate-resistant acid phosphatase）为破骨细胞的标志酶，特异地分布于破骨细胞中，为破骨细胞所特有。通常作为鉴别破骨细胞的重要标志物，使破骨细胞呈红色。  

TRAP Staining Kit

       艾美捷科技作为专业的生命科学领域解决方案供应商，为您推荐39年老品牌，Kamiya畅销产品，众多Nature文章使用认证！

       * 产品仅限用于科研学术研究用途，不得用于医疗与诊断。  

       TRAP Staining Kit，Nature文章结果鉴赏：

       ①【Nature Medicine, IF=87.2】  

TRAP stain: TRAP染色 (osteoclasts (o/c))

        ② 【Nature Biomedical Engineering, IF=29.2】A multi-organ chip with matured tissue niches linked by vascular flow  

TRAP stain: TRAP染色

TRAP Activity: TRAP活性

       【更多发表文章】

      Sherlock, Jonathan P et al. "IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells". Nature medicinevol.18,7 (2012): 1069-76.

      Ronaldson-Bouchard, Kacey et al. "A multi-organ chip with matured tissue niches linked by vascular flow". Nature biomedical engineering vol.6,4 (2022): 351-371. doi:10.1038/s41551-022-00882-6

      Bae, Sung-Jin et al. "Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts". Experimental & molecular medicine vol.51,1 (2019): 1-16.

      Kang, J., Choi, Y.J., Seo, B.Y. et al. A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment. Sci Rep 9, 8726 (2019).

      Zhang, Lan, et al. "Adiponectin ameliorates experimental periodontitis in diet-induced obesity mice."PloS one 9.5 (2014): e97824.

      Kang, Moo Rim et al. "Agelasine D suppresses RANKL-induced osteoclastogenesis via down-regulation of c-Fos, NFATc1 and NF-κB". Marine drugs vol.12,11 (2014): 5643-56.

      Sherlock, Jonathan P., et al. "IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+ CD4? CD8? entheseal resident T cells."Nature medicine18.7 (2012): 1069-1076.

      Kim, Jinkoo, et al. "Erythropoietin mediated bone formation is regulated by mTOR signaling."Journal of cellular biochemistry113.(2012): 220-228.

      Lee, Yu-Chen, et al. "Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts."Oncogene 29.22 (2010): 3196-3207.

      Lu, Yi et al. "Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone". Clinical & experimental metastasis vol.26,2 (2009): 161-9. doi:10.1007/s10585-008-9226-7

      Geng, Weidong et al. "Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase". Journal of cellular physiology vol.220,2 (2009): 332-40.

      Simonaro, Calogera M., et al. "Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases."The American journal of pathology172.1(2008): 112-122.

       Kamiya Biomedical Company于1983年成立于美国加利福尼亚，1996年公司迁至华盛顿。Kamiya公司旨在为生命科学和医学界提供高品质的创新的实验室研究和诊断工具。产品线包括数千种用于临床前研究的人类和动物生物标志物的检测，是选择非常多的ELISA试剂盒供应商之一。Kamiya还提供各种其它生命科学研究产品，包括酶抑制剂和单克隆/多克隆抗体，用于多种领域，包括细胞凋亡、多药耐药性、氧化损伤/DNA损伤和修复、骨生物学、癌症、心脏健康、炎症、应激、肥胖和糖尿病等。最近，Kamiya推出了新的创新K-ASSAY化学分析仪试剂，用于胰岛素、D-二聚体、因子XIII、血浆FDP、血清/尿液FDP和总IgE检测等。   

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